Mitochondrial dysfunction in heart failure: potential for therapeutic interventions?
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منابع مشابه
Mitochondrial dysfunction in heart failure: potential for therapeutic interventions?
a , b,c * William C. Stanley , Charles L. Hoppel Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA Departments of Pharmacology and Medicine, Case Western Reserve University, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA Veterans Affairs Medical...
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Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. These events allow the transmission of signaling messengers and exchange of metabolites within the cell. They have also been implicated in a variety of biological processes ...
متن کاملMitochondrial dysfunction in heart failure.
angina was reached. Angina, unfortunately, is a subjective measure. Irrespective of how “objective” the investigators were in determining the success or failure of antianginal therapy, the use of a subjective end point may have inadvertently introduced bias into the trial. It is difficult to draw proper conclusions from such a trial when large crossover rates are allowed. With respect to the Eu...
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Advanced glycation end products (AGE) have been implicated in diabetes associated complications. They have been suggested as potential mediators in the progression of diabetic heart failure and as a potential target for treatment. Brunvand et al. now provided evidence in that the suggested causal relationship between AGE and diastolic myocardial dysfunction cannot be confirmed in children with ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2000
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(99)00419-8